KBM (생물, 의학, 약학관련 연구 모임) 6월 학술 세미나 안내 [6/21 Tue 6 pm] > 자유게시판

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KBM (생물, 의학, 약학관련 연구 모임) 6월 학술 세미나 안내 [6/21 Tue 6 pm]

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작성자 Science (35.♡.6.28) 댓글 0건 조회 95회 작성일 2022-06-07 16:38



KBM (Korean Biological Research Group in Michigan)은 의학, 약학, 생물학 관련 연구를 수행하는 연구자들의 모임입니다 [홈페이지]. 

매달 셋째 주 화요일 저녁 6시에 온라인으로 학술 세미나 및 네트워킹을 진행하고 있으며, 현재 UofM 뿐만 아니라 다른 학교와의 교류도 도모하고 있습니다. 

KBM Science Series.

6월 세미나 안내입니다.

이번 달은 Computational medicine and bioinformatics 을 전공하고 있는 조한별님께서 “Murine Prostate Luminal Epithelial Diversity Captured by Single Cell RNA Sequencing” 란 주제로 발표해 주십니다.

   Abstract

Prostate cancer is one of the leading causes of cancer-related mortality among the aging western male population.  Previous seminal studies have characterized the distinct molecular driver aberrations in prostate cancers including, the recurrent ETS gene fusions, SPOP mutations, PTEN copy loss among others in prostatic adenocarcinoma, and NMYC gene amplification among the neuroendocrine prostate cancers.  TCGA flagship study that characterized 333 primary localized prostate cancer patient (predominantly Caucasian population) samples, revealed several distinct molecular subtypes, that include ETS gene fusions (~60%), SPOP mutant (11%) other (long tail, heterogeneous class 26%). PTEN loss was noted in 17% of the cases and mainly co-occurred with ETS gene fusions. While ETS gene fusions were sufficient to drive human prostate cancer, replicating this aberration in mouse luminal epithelial cells produced only pre-cancerous mouse prostatic intraepithelial neoplasia (mPIN) and not the full disease. In the murine model loss of PTEN was essential to drive the neoplasm and hence existing genetically engineered prostate cancer murine models such as HIMYC and PTEN-null models have several limitations. They lack faithful representation of the human disease, in terms of disease initiation, progression, and comprehensive molecular driver aberrations. Unlike the human prostate gland, the murine equivalent is multilobulated and hence we hypothesize that murine prostate luminal epithelial cells may have lobe specific epithelial cell diversity and a comparative study of the transcriptional programs that occur in human and murine prostate luminal epithelial cells will help identify the appropriate cell type that can be transformed by human PCa molecular drivers.

l  장소: Biological Sciences Building (BSB), Room 5150

l  주소: 1105 N University Ave, Ann Arbor, MI 48109

l  시간: 6월 21일(화) 오후 6시

l  Zoom link: https://umich.zoom.us/j/2016101518 (passcode:3mDLiz)

세미나는 In-person과 ZOOM 으로 동시 진행되오니, 편하신 방법으로 참석해 주세요. 더불어, 세미나 이후 식사가 예정되어 있습니다.

많은 관심과 참석 부탁드립니다. 감사합니다.



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