페이지 정보작성자 Science (35.♡.6.28) 댓글 0건 조회 186회 작성일 2022-05-17 14:07
KBM (Korean Biological Research Group in Michigan)은 의학, 약학, 생물학 관련 연구를 수행하는 연구자들의 모임입니다 [홈페이지].
매달 셋째 주 화요일 저녁 6시에 온라인으로 학술 세미나 및 네트워킹을 진행하고 있으며, 현재 UofM 뿐만 아니라 다른 학교와의 교류도 도모하고 있습니다.
KBM Science Series.
5월 세미나 안내입니다.
Medical School, Mucosal Immunology 소속으로 계시는 김예지 박사님께서 “Dietary cellulose prevents gut inflammation by modulating lipid metabolism
and gut microbiota” 란 주제로 발표해 주십니다.
A Western diet comprising high fat, high carbohydrate, and low fiber content has been suggested to contribute to an increased prevalence of colitis. To clarify the effect of dietary cellulose (an insoluble fiber) on gut homeostasis, for 3 months mice were fed a high-cellulose diet (HCD) or a low-cellulose diet (LCD) based on the AIN-93G formulation. Histologic evaluation showed crypt atrophy and goblet cell depletion in the colons of LCD-fed mice. RNA-sequencing analysis showed a higher expression of genes associated with immune system processes, especially those of chemokines and their receptors, in the colon tissues of LCD-fed mice than in those of HCD-fed mice. The HCD was protective against dextran sodium sulfate-induced colitis in mice, while LCD exacerbated gut inflammation; however, the depletion of gut microbiota by antibiotic treatment diminished both beneficial and non-beneficial effects of the HCD and LCD on colitis, respectively. A comparative analysis of the cecal contents of mice fed the HCD or the LCD showed that the LCD did not influence the diversity of gut microbiota, but it resulted in a higher and lower abundance of Oscillibacter and Akkermansia organisms, respectively. Additionally, linoleic acid, nicotinate, and nicotinamide pathways were most affected by cellulose intake, while the levels of short-chain fatty acids were comparable in HCD- and LCD-fed mice. Finally, oral administration of Akkermansia muciniphila to LCD-fed mice elevated crypt length, increased goblet cells, and ameliorated colitis. These results suggest that dietary cellulose plays a beneficial role in maintaining gut homeostasis through the alteration of gut microbiota and metabolites.
5월 세미나는 연사분의 사정으로 인하여 ZOOM 으로만 진행함을 알려드립니다. 많은 관심과 참석 부탁드립니다.
등록된 댓글이 없습니다.