KBM (생물, 의학, 약학관련 연구 모임) 11월 학술 세미나 안내 [11/16 Tue 6 pm] > 자유게시판

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KBM (생물, 의학, 약학관련 연구 모임) 11월 학술 세미나 안내 [11/16 Tue 6 pm]

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작성자 Science (67.♡.235.73) 댓글 0건 조회 68회 작성일 2021-11-14 23:30



KBM (Korean Biological Research Group in Michigan)은 의학, 약학, 생물학 관련 연구를 수행하는 연구자들의 모임입니다 [홈페이지]. 

매달 셋째 주 화요일 저녁 6시에 온라인으로 학술 세미나 및 네트워킹을 진행하고 있으며, 현재 UofM 뿐만 아니라 다른 학교와의 교류도 도모하고 있습니다. 

KBM Science Series. 

11월 세미나 안내입니다. 

Department of Nutritional Sciences 소속으로 계시는 최은경 박사님께서 “Intestinal epithelial SLC39A8 regulates manganese homeostasis and inhibits experimental colitis” 란 주제로 발표해 주십니다.

   Abstract:

To determine the contribution of intestinal epithelial-specific SLC39A8, we generated a novel genetic model of an intestinal epithelial cell-specific Slc39a8 knockout mouse (Slc39a8-IEC KO). SLC39A8 IEC-KO mice have significantly reduced Mn levels in the intestine coupled with marked reduced Mn concentrations in blood and other organs. Despite the known ability of SLC39A8 to transport zinc and iron, tissue zinc and iron levels were not different in Slc39a8-IEC KO mice compared with levels in controls. 

In experimental colitis models induced by dextran sulfate sodium, Slc39a8-IEC KO mice were highly susceptible to colitis, as manifested by markedly increased morbidity, weight loss, and colon injury, and colonic inflammation compared with controls. Without DSS treatment, Slc39a8-IEC KO mice displayed elevated intestinal permeability by impairing intestinal tight junctions.

Our unbiased transcriptomic analysis reveals that alkaline ceramidase 1 (ACER1), a lipid-generating enzyme that affects intestinal permeability, is significantly up-regulated in the intestines of Slc39a8-IEC KO mice. Based on the observations, we are currently testing whether ACER inhibitor can reduce intestinal permeability and alter the susceptibility of experimental colitis. 

Together, this work suggests that intestinal epithelial Slc39a8 is required for intestinal absorption of dietary Mn, and that loss of Slc39a8 exacerbates experimental colitis likely by impairing intestinal barrier functions. 

   장소: Biological Sciences Building (BSB), Room 5150 

   주소: 1105 N University Ave, Ann Arbor, MI 48109

   시간: 11월 16일(화) 오후 6시

   Zoom link: https://umich.zoom.us/j/2016101518 (passcode:3mDLiz)

세미나는 In-person과 ZOOM 으로 동시 진행되오니, 편하신 방법으로 참석해 주세요. 더불어, 세미나 이후 식사가 예정되어 있습니다.

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